Cat.NO.:A1179870 Purity:98%
Product Details of [ 100953-52-4 ]
| CAS No. : | 100953-52-4 |
| Formula : |
C12H11BrN2 |
| M.W : |
263.13
|
| SMILES Code : | BrC1=CC=C(C=C1)NC2=C(N)C=CC=C2 |
| MDL No. : | MFCD11201944 |
| InChI Key : | LCLAHXCIHJAZIF-UHFFFAOYSA-N |
| Pubchem ID : | 21450593 |
Safety of [ 100953-52-4 ]
| GHS Pictogram: |  |
| Signal Word: | Warning |
| Hazard Statements: | H302-H315-H319-H335 |
| Precautionary Statements: | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Application In Synthesis of [ 100953-52-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 100953-52-4 ]
[ 100953-52-4 ] Synthesis Path-Downstream 1~2
- 1
[ 100953-52-4 ]
[ 867044-33-5 ]
- 2
[ 5555-00-0 ]
- [ 100953-52-4 ]
- N-(2-((4-bromophenyl)amino)phenyl)-2-methylfuran-3-carboxamide [ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With triethylamine; In dichloromethane; at 20℃; for 2h; | General procedure: To a solution of compounds 4a-j (0.02 mol) in triethylamine (5 mL) and dichloromethane (15 mL)in an ice bath, freshly prepared 3-furoyl chloride was added dropwise and theresulting mixture was stirred at room temperature for 2 hours. The mixture wasthen filtered, successively washed with aqueous sodium hydroxide (5%, 3 x 15mL) and water (2 x 15 mL). The organic phase wasthen dried over anhydrous sodium sulfate, filtered and evaporated in vacuo to remove dichloromethane.Finally, the residue was purified by column chromatography to yield the finaltarget compounds 5a-j.4 2-methyl-N-(2-(phenylamino)phenyl)furan-3-carboxamide(5a).Yield, 62.8 %; white solid; mp, 133.8-134.6 ; 1HNMR (400 MHz, DMSO) delta 9.25 (s, 1H), 7.60 – 7.52 (m, 2H), 7.44 (s, 1H), 7.30 (dd, J =8.1, 1.1 Hz, 1H), 7.20 (d, J = 7.5 Hz, 1H), 7.19 – 7.12 (m, 2H), 7.04 -6.97 (m, 1H), 6.91 (s, 1H), 6.89 (s, 1H), 6.87 (d, J = 1.7 Hz, 1H), 6.79(t, J = 7.3 Hz, 1H), 2.53 (d, J = 3.3 Hz, 3H). 13C NMR(400 MHz, DMSO): delta 161.70, 156.40, 143.87, 140.53, 136.28, 128.89, 125.75, 125.54, 121.53,120.01, 119.19, 116.05, 109.23, 13.05. ESI MS: m / z 314.98 [M + Na]+. |
Reviews
There are no reviews yet.