Cat.NO.:A350385 Purity:98%
Product Details of [ 1006037-03-1 ]
| CAS No. : | 1006037-03-1 |
| Formula : |
C11H13NO2 |
| M.W : |
191.23
|
| SMILES Code : | O=C(OC)C1=CC=C(C2(N)CC2)C=C1 |
| MDL No. : | MFCD11616340 |
| InChI Key : | JUMQWXLIAYMPHT-UHFFFAOYSA-N |
| Pubchem ID : | 45140209 |
Safety of [ 1006037-03-1 ]
| GHS Pictogram: |  |
| Signal Word: | Warning |
| Hazard Statements: | H302-H315-H319-H335 |
| Precautionary Statements: | P261-P305+P351+P338 |
Application In Synthesis of [ 1006037-03-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 1006037-03-1 ]
[ 1006037-03-1 ] Synthesis Path-Upstream 1~1
- 1
[ 1006037-03-1 ]
[ 1014645-87-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 100% | With hydrogenchloride In diethyl ether; ethyl acetate | Step 2:To a solution of ER-886774-00 (1.63 g, 0.0085 mol) in ethyl acetate (10 mL) was added 2.0 M of hydrogen chloride in Ether (6.0 mL, 0.012 mol). After stirring for several minutes, the reaction mixture was concentrated to give the title compound (quantitative yield) as pale brown solid. |
| 68.7 g | With hydrogenchloride In ethyl acetate at 20℃; for 2 h; | To a cooled solution of methyl 4-(1-aminocyclopropyl)benzoate (D6) (100 g, 524 mmol) in ethyl acetate (500 ml) 4N HCl (g)/ethyl acetate solution (300 ml) was added and the resulting mixture was stirred at room temperature for 2 hours. Evaporated the solvent, the residue was recrystallized with petroleum ether/EtOAc to afford the title compound (D7) (68.7 g) as a white solid. |
[1] Patent: WO2012/39972, 2012, A1, . Location in patent: Page/Page column 39.
[2] Journal of Organic Chemistry, 2010, vol. 75, # 12, p. 4078 – 4085.
[3] Patent: WO2012/76063, 2012, A1, . Location in patent: Page/Page column 39.
[4] Patent: US2013/261100, 2013, A1, . Location in patent: Paragraph 0273-0274; 02796.
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