2-Phenylpyrrolidine

Cat.NO.:A166328 Purity:97%

Product Details of [ 1006-64-0 ]

CAS No. :	1006-64-0
Formula :	C₁₀H₁₃N
M.W :	147.22
SMILES Code :	C1CNC(C1)C1=CC=CC=C1
MDL No. :	MFCD01631835
InChI Key :	JUTDHSGANMHVIC-UHFFFAOYSA-N
Pubchem ID :	261892

Safety of [ 1006-64-0 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P261-P280-P305+P351+P338

Application In Synthesis of [ 1006-64-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1006-64-0 ]

[ 1006-64-0 ] Synthesis Path-Downstream 1~35

1
[ 132959-49-0 ]
[ 1006-64-0 ]

References: [1]Journal of Organic Chemistry,1992,vol. 57,p. 1656 – 1662.

2
[ 882-33-7 ]
[ 1006-64-0 ]

References: [1]Journal of Organic Chemistry,1991,vol. 56,p. 2294 – 2296.

3
(S)-3-Methyl-2-((S)-2-phenyl-pyrrolidin-1-yl)-butyric acid methyl ester [ No CAS ]
[ 1006-64-0 ]

References: [1]Tetrahedron Letters,1994,vol. 35,p. 2775 – 2778.

4
[ 700-91-4 ]
[ 1006-64-0 ]

References: [1]Journal of the American Chemical Society,1996,vol. 118,p. 6784 – 6785.
[2]ACS Catalysis,2016,vol. 6,p. 3880 – 3889.
[3]ChemCatChem,2018,vol. 10,p. 3236 – 3246.

5
[ 79-37-8 ]
[ 1006-64-0 ]
1,2-Bis-((S)-5-phenyl-pyrrolidin-3-yl)-ethane-1,2-dione [ No CAS ]

References: [1]Journal of the American Chemical Society,1996,vol. 118,p. 715 – 721.

6
[ 174310-75-9 ]
[ 1006-64-0 ]

References: [1]Journal of the American Chemical Society,1996,vol. 118,p. 715 – 721.
[2]Tetrahedron Letters,2000,vol. 41,p. 8157 – 8162.

7
[ 1006-64-0 ]
[ 99-33-2 ]
2-phenyl-N-(3,5-dinitrobenzoyl)-pyrrolidine [ No CAS ]

References: [1]Journal of the American Chemical Society,1996,vol. 118,p. 715 – 721.

8
[ 106-39-8 ]
[ 1006-64-0 ]
(S)-N-(4-chlorophenyl)-2-phenylpyrrolidine [ No CAS ]

References: [1]Journal of the American Chemical Society,1997,vol. 119,p. 8451 – 8458.

9
[ 92-66-0 ]
[ 1006-64-0 ]
1-Biphenyl-4-yl-2-phenyl-pyrrolidine [ No CAS ]

References: [1]Journal of the American Chemical Society,1997,vol. 119,p. 8451 – 8458.

10
(S)-ethyl 2-(2-phenylpyrrolidin-1-yl)-2-oxoacetate [ No CAS ]
[ 1006-64-0 ]

References: [1]Organic Letters,2005,vol. 7,p. 4329 – 4331.

11
[ 39637-99-5 ]
[ 1006-64-0 ]
C₂₀H₂₀F₃NO₂ [ No CAS ]

References: [1]Organic Letters,2007,vol. 9,p. 4123 – 4126.

12
[ 20445-33-4 ]
[ 1006-64-0 ]
(2S)-2-phenylpyrrolidine-(S)-MTPA-amide [ No CAS ]

References: [1]Organic Letters,2007,vol. 9,p. 4123 – 4126.
[2]Chemical Communications,2010,vol. 46,p. 3122 – 3124.

13
[ 350479-90-2 ]
[ 1006-64-0 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 8157 – 8162.

14
[ 316813-41-9 ]
[ 1006-64-0 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 8157 – 8162.

15
[ 316813-68-0 ]
[ 1006-64-0 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 8157 – 8162.

16
[ 316813-12-4 ]
[ 1006-64-0 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 8157 – 8162.

17
[ 316813-66-8 ]
[ 1006-64-0 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 8157 – 8162.

18
[ 316813-29-3 ]
[ 1006-64-0 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 8157 – 8162.

19
[ 316813-33-9 ]
[ 1006-64-0 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 8157 – 8162.

20
4-methyl-benzenesulfinic acid (2-benzenesulfonyl-1-phenyl-but-3-enyl)-amide [ No CAS ]
[ 1006-64-0 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 8157 – 8162.

21
[ 1006-64-0 ]
1,2-Bis(S)-(2-phenylpyrrolidinyl)ethane [ No CAS ]

References: [1]Journal of the American Chemical Society,1996,vol. 118,p. 715 – 721.

22
[ 174311-01-4 ]
[ 1006-64-0 ]

References: [1]Journal of the American Chemical Society,1996,vol. 118,p. 715 – 721.

23
Methanesulfinic acid 3-(benzyl-tert-butoxycarbonyl-amino)-propyl ester [ No CAS ]
[ 1006-64-0 ]

References: [1]Journal of the American Chemical Society,1996,vol. 118,p. 715 – 721.
[2]Journal of the American Chemical Society,1996,vol. 118,p. 715 – 721.

24
[ 56139-59-4 ]
[ 1006-64-0 ]

References: [1]Tetrahedron Letters,1994,vol. 35,p. 2775 – 2778.

25
[ 132959-45-6 ]
[ 1006-64-0 ]

References: [1]Journal of Organic Chemistry,1992,vol. 57,p. 1656 – 1662.

26
[ 132959-39-8 ]
[ 1006-64-0 ]

References: [1]Journal of Organic Chemistry,1992,vol. 57,p. 1656 – 1662.
[2]Organic and Biomolecular Chemistry,2011,vol. 9,p. 2175 – 2184.

27
[ 2051-95-8 ]
[ 1006-64-0 ]

References: [1]Journal of Organic Chemistry,1992,vol. 57,p. 1656 – 1662.
[2]Organic and Biomolecular Chemistry,2011,vol. 9,p. 2175 – 2184.

28
[ 796600-15-2 ]
[ 1006-64-0 ]
2-chloro-3-methyl-4-(2-phenyl-pyrrolidin-1-yl)-benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
37%	With 4-methyl-morpholine; at 150℃;	Heat <strong>[796600-15-2]2-chloro-4-fluoro-3-methyl-benzonitrile</strong> (144 mg, 0.85 mmol) and 2- . phenyl-pyrrolidine (0.15 g, 1.02 mmol, 1.20 equivalents) in N-methylmorpholine (0.11 ml, 1.02 mmol, 1.20 equivalents) at 150 0C overnight. Allow the reaction mixture to cool to room temperature, dilute with dichloromethane (1 ml), load on silica, and purify by chromatography (12 g silica gel, 0 to 100% ethyl acetate/hexanes over 20 minutes) to obtain 150 mg of an oily residue. Recrystallize from ethyl acetate/hexanes to obtain the title compound (92 mg, 37%). LCMS(APCI+): 297.0 (M+l)+; 1H NMR (400 MHz, CDCl3): delta 7.25 (s, 2H), 7.19 (m, 2H), EPO <DP n=”58″/>6.65 (d, IH), 4.70 (m, IH), 4.06 (m, IH), 3.18 (m, IH), 2.44 (m, IH), 2.43 (s, 3H), 2.12 (m, IH), 1.94 (m, 2H).