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1-EBIO

1-EBIO

1-EBIO

CAS No.: 10045-45-1

Category Products

Cat.NO.:A147983 Purity:97%

Product Details of 1-EBIO

CAS No. :	10045-45-1
Formula :	C₉H₁₀N₂O
M.W :	162.19
SMILES Code :	O=C1N(CC)C2=CC=CC=C2N1
Synonyms :	1-Ethyl-2-benzimidazolinone; 1-Ethylbenzimidazolinone
MDL No. :	MFCD00005715
InChI Key :	CXUCKELNYMZTRT-UHFFFAOYSA-N
Pubchem ID :	82320

Safety of 1-EBIO

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H319
Precautionary Statements:	P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	6.17mL 1.23mL 0.62mL	30.83mL 6.17mL 3.08mL	61.66mL 12.33mL 6.17mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

References

[1]References are publications that support the biological activity of the product.

Ayotunde and Adeagbo
(1999)
1-Ethyl-2-benzimidazolinone stimulates endothelial KCa channels and nitric oxide formation in rat mesenteric vessels.
Eur.J.Pharmacol. 379
151 PMID: 10497901
Devor
et al
(1996)
Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca2+ – dependent K+ channel.
Am.J.Physiol. 271
L775 PMID: 8944721
Kusama
et al
(2005)
Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration.
Br.J.Pharmacol. 146
487 PMID: 16056232
Kleger
et al
(2010)
Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells.
Circulation. 122
1823 PMID: 20956206
If you know of a relevant reference for 1-EBIO, please let us know.

[2]Roth EK, Hirtz S, Duerr J, Wenning D, Eichler I, Seydewitz HH, Amaral MD, Mall MA. The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients. PLoS One. 2011;6(8):e24445

[3]Yin MZ, Park SW, Kang TW, Kim KS, Yoo HY, Lee J, Hah JH, Sung MH, Kim SJ. Activation of K(+) channel by 1-EBIO rescues the head and neck squamous cell carcinoma cells from Ca(2+) ionophore-induced cell death. Korean J Physiol Pharmacol. 2016 Jan;20(1):25-33

[4]Alvarez LJ, Zamudio AC, Candia OA. Cl- secretory effects of EBIO in the rabbit conjunctival epithelium. Am J Physiol Cell Physiol. 2005 Jul;289(1):C138-47

[5]Edwards G, Gardener MJ, Feletou M, Brady G, Vanhoutte PM, Weston AH. Further investigation of endothelium-derived hyperpolarizing factor (EDHF) in rat hepatic artery: studies using 1-EBIO and ouabain. Br J Pharmacol. 1999 Nov;128(5):1064-70

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