Cat.NO.:A1523655 Purity:99%
Product Details of Azetukalner
| CAS No. : | 1009344-33-5 |
| Formula : |
C23H29FN2O |
| M.W : |
368.49
|
| SMILES Code : | CC(C)(C)CC(NC1=C(C)C=C(N2CC3=C(C=C(F)C=C3)CC2)C=C1C)=O |
| Synonyms : |
XEN1101
|
| MDL No. : | N/A |
| InChI Key : | FJNPZKZPWVVSON-UHFFFAOYSA-N |
| Pubchem ID : | 24743936 |
Safety of Azetukalner
| GHS Pictogram: |  |
| Signal Word: | Warning |
| Hazard Statements: | H315-H319 |
| Precautionary Statements: | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Isoform Comparison
| Name | Potassium Channel ↓ ↑ | Purity | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tolbutamide | ✔ | 98% | |||||||||||||||||
| Glimepiride | ++++ | 97% | |||||||||||||||||
| Dronedarone HCl | ✔ | 95% | |||||||||||||||||
| Gliquidone | ++ | 99% | |||||||||||||||||
| TRAM-34 | +++ | 98% | |||||||||||||||||
| Glibenclamide | ✔ | 98% | |||||||||||||||||
| Amiodarone HCl | ✔ | 97% | |||||||||||||||||
| Gliclazide | ++ | 98% | |||||||||||||||||
| Repaglinide | ✔ | 98% | |||||||||||||||||
| Dofetilide | ✔ | 98% | |||||||||||||||||
| Nateglinide | ✔ | 99% | |||||||||||||||||
| Quinine HCl dihydrate | ✔ | 98% | |||||||||||||||||
| ML133 HCl | + | 99% | |||||||||||||||||
Biological Activity
| Description |
KCNQ2/3 activator-1 serves as an activator of the Kv7.2/Kv7.3 (KCNQ2/3) potassium channel and holds promise in alleviating pain, a primary concern in medical treatment[1].
|
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
| NCT05718817 | Focal Epilepsy|Tonic-Clonic Se… More >>izures Less << | PHASE3 | ENROLLING_BY_INVITATION | 2025-09-28 | Clinical Trials, Inc, Little R… More >>ock, Arkansas, 72205, United States|UC Irvine Health, Orange, California, 92868, United States|Research Institute of Orlando, LLC, Orlando, Florida, 32806, United States|Panhandle Research & Medical Clinic, Pensacola, Florida, 10021, United States|Hawaii Pacific Neuroscience, Honolulu, Hawaii, 96817, United States|Consultants in Epilepsy and Neurology, Boise, Idaho, 83704, United States|Indiana University School of Medicine, Indianapolis, Indiana, 46202, United States|Bluegrass Epilepsy Research, LLC, Lexington, Kentucky, 40504, United States|Kentucky Clinic, Lexington, Kentucky, 40536, United States|MMP Neurology, Scarborough, Maine, 04074, United States|Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland, 20817, United States|University of Michigan Hospitals, Ann Arbor, Michigan, 48109-2435, United States|Michigan State University, East Lansing, Michigan, 48824, United States|Cornwell Health (Spectrum Health Hospitals), Grand Rapids, Michigan, 49503, United States|Northeast Epilepsy Group, Hackensack, New Jersey, 07601, United States|Montefiiore Medical Center, Bronx, New York, 10467, United States|Dent Neurosciences Research Center, Buffalo, New York, 14226, United States|New York University Comprehensive Epilepsy Center, New York, New York, 10016, United States|Mount Sinai Health, New York, New York, 10029, United States|SUNY Upstate Medical University, Syracuse, New York, 13210, United States|Duke University, Durham, North Carolina, 27710, United States|Summa Health, Akron, Ohio, 44304, United States|Providence Neurological Specialities, Portland, Oregon, 97225, United States|Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, United States|Vanderbilt University Medical Center, Nashville, Tennessee, 37232, United States|University of Utah Clinical Neurosciences Center, Salt Lake City, Utah, 84132, United States|Carilion Clinic, Roanoke, Virginia, 24013, United States|Sentara Neurology Specialists, Virginia Beach, Virginia, 23456, United States|University of Washington Main Hospital, Seattle, Washington, 10012, United States|Aurora St. Luke’s Medical Center, Milwaukee, Wisconsin, 53215, United States|STAT Research S.A., Buenos Aires, C1023AAB, Argentina|Hospital De Alta Complejidad en Red El Cruce – Dr Nester Carlos Kirchner Servicio de Atencion Medica Integral Para la Communidad, Florencio Varela, 1888, Argentina|Sanatorio del SUR S.A., Tucumán, 4000, Argentina|Royal Prince Alfred Hospital, Camperdown, 2050, Australia|Austin Health Pharmacy Clinical Trials, Heidelberg, 3084, Australia|Southern Neurology, Kogarah, 2217, Australia|Alfred Hospital Neurology CT Dept of Neuroscience, Melbourne, 30004, Australia|The Royal Melbourne Hospital, Parkville, 3050, Australia|Westmead Hospital Dept. of Neurology Epilepsy Unit, Westmead, 2145, Australia|University Hospital Innsbruck, Innsbruck, 6020, Austria|Hospital for active treatmnt Puls AD Neurology Dpt, Blagoevgrad, 2700, Bulgaria|MHATNP St. Naum, Sofia, 1113, Bulgaria|Center for Neurologic Research, Lethbridge, Alberta, T1J 0N9, Canada|Centro de investigación Clinica UC, Santiago, 8330073, Chile|University Hospital Centre Zagreb, Zagreb, 10000, Croatia|Motol University Hospital, Prague, 150 06, Czechia|Forbeli s.r.o., Prague, 160 00, Czechia|Universit?tsklinikum, ZNN – Epilepsiezentrum Frankfurt Rhein-Main, Frankfurt, 60528, Germany|Universitaets-Und Rehabilitations Ulm (RKU), Ulm, 89081, Germany|Semmelweis Egyetem, Idegsebeszeti es Neurointervencios Klinika, Budapest, 1145, Hungary|Hadassah Medical Center (HMC), Jerusalem, 9112001, Israel|The Tel Aviv Sourasky Medical Center, Tel Aviv, 6423906, Israel|IRCCS Istituto delle Scienze Neurologiche Bologna, Bologna, 40139, Italy|Centrum Medyczne Neuromed, Bydgoszcz, 85-163, Poland|COPERNICUS Podmiot Leczniczy Sp. z o.o., Gdańsk, 80-803, Poland|NZOZ Neuromed M. i M., Lublin, 20-064, Poland|Twoja Przychodnia Nowosolskie Centrum Medyczne, Nowa Sól, 67-100, Poland|MTZ Clinical Research Powered by Pratia, Warsaw, 02-172, Poland|Centro Hospitalar Universitário de Coimbra (CHUC), Coimbra, 3000-075, Portugal|Hospital Senhora da Oliviera de Guimaraes, Guimar?es, 4835-044, Portugal|Unidade Local Saúde Matosinhos, Porto, 4464-513, Portugal|Centro Hospitalar de Entre o Douro e Vouga, Santa Maria Da Feira, 520-211, Portugal|Hospital Universitario Cruces, Baracaldo, 48903, Spain|Vall d’Hebron Hospital, Barcelona, 08035, Spain|Hospital Vithas La Milagrosa, Madrid, 28010, Spain|Hospital Ramón Y Cajal, Madrid, 28034, Spain|Hospital Ruber Internacional, Madrid, 28034, Spain|Hospital Clinico San Carlos, Madrid, 28040, Spain|Hospital Universitario Fundación Jiménez Díaz, Madrid, 28040, Spain|Hospital Regional De Malaga, Málaga, 29010, Spain|Hospital La Fe, Valencia, 46026, Spain|Hospital Clinico Universitario de Valladolid, Valladolid, 47003, Spain|Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, United Kingdom|University College London, London, WC1N 3BG, United Kingdom Less << |
| NCT03796962 | Focal Epilepsy | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-10-28 | University of Alabama at Birmi… More >>ngham, Birmingham, Alabama, 35294, United States|Strada Patient Care Center, Mobile, Alabama, 36604, United States|Xenoscience, Inc., Phoenix, Arizona, 85004, United States|Clinical Trials, Inc., Little Rock, Arkansas, 72205, United States|Altman Clinical Translational Research Institute (ACTRI), La Jolla, California, 92037, United States|California Pacific Medical Center (CPMC) – Sutter Pacific Epilepsy Program, San Francisco, California, 94109, United States|University of Colorado Hospital Anschutz Outpatient Pavilion, Aurora, Colorado, 80045, United States|University of Florida Jacksonville, Jacksonville, Florida, 32209, United States|Mayo Clinic Florida, Jacksonville, Florida, 32224, United States|Visionary Investigators Network, Miami, Florida, 33133, United States|Don Clinical Research Center, Miami, Florida, 33136, United States|The Neurology Research Group, LLC., Miami, Florida, 33176, United States|Research Institute of Orlando, LLC, Orlando, Florida, 32806, United States|Medsol Clinical Research Center, Port Charlotte, Florida, 33952, United States|Tallahassee Neurological Clinic, Tallahassee, Florida, 32308, United States|University of South Florida, Tampa, Florida, 33606, United States|Georgia Neurology and Sleep Medicine Associate, Suwanee, Georgia, 30024, United States|Hawaii Pacific Neuroscience, Honolulu, Hawaii, 96817, United States|Consultants in Epilepsy and Neurology, PLLC, Boise, Idaho, 83702, United States|Northwestern Medical Group, Department of Neurology, Chicago, Illinois, 60611, United States|University of Kansas Medical Center, Kansas City, Kansas, 66160, United States|Bluegrass Epilepsy Research, Lexington, Kentucky, 40504, United States|Maine Medical Partners Neurology, Scarborough, Maine, 04074, United States|Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland, 20817, United States|Boston Neuro Research Center, South Dartmouth, Massachusetts, 02747, United States|Minneapolis Clinic of Neurology, Ltd., Golden Valley, Minnesota, 55422, United States|Minnesota Epilepsy Group, P. A., Saint Paul, Minnesota, 55102, United States|Northeast Regional Epilepsy Group, Hackensack, New Jersey, 07601, United States|Institute of Neurology and Neurosurgery at Saint Barnabas, Livingston, New Jersey, 07039, United States|Northeast Regional Epilepsy Group, Morristown, New Jersey, 07960, United States|Dent Neurosciences Research Center, Amherst, New York, 14226, United States|NYU Langone Medical Center/NYU School of Medicine, New York, New York, 10016, United States|Northwell Health – Lenox Hill, New York, New York, 10075, United States|SUNY Upstate Medical University Institute for Human Performance, Syracuse, New York, 13210, United States|Five Towns Neuroscience Research, Woodmere, New York, 11598, United States|Asheville Neurology Specialists, PA, Asheville, North Carolina, 28806, United States|UC Gardner Neuroscience Institute, Cincinnati, Ohio, 45219, United States|Miami Valley Hospital, Dayton, Ohio, 45409, United States|University of Toledo Medical Center, Toledo, Ohio, 43606, United States|Providence Neurological Specialties East, Portland, Oregon, 97213, United States|Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Thomas Jefferson University Comprehensive Epilepsy Center, Philadelphia, Pennsylvania, 19107, United States|Allegheny Neurological Associates, Pittsburgh, Pennsylvania, 15212, United States|Vanderbilt Epilepsy Clinic, Nashville, Tennessee, 37232, United States|Austin Epilepsy Care Center, Austin, Texas, 78758, United States|James W. Aston Ambulatory Care Center, Dallas, Texas, 75390, United States|The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229-3900, United States|University of Utah Health Clinical Neurosciences Center, Salt Lake City, Utah, 84132, United States|University of Virginia, Charlottesville, Virginia, 22903, United States|Virginia Commonwealth University, Richmond, Virginia, 23219, United States|Carilion Neurology Clinic, Roanoke, Virginia, 24016, United States|Winchester Neurological Consultants, Winchester, Virginia, 22601, United States|UW Medicine Valle Medical Center, Renton, Washington, 98055, United States|University of Washington School of Medicine, Regional Epilepsy Center at Harborview Medical Center, Seattle, Washington, 98104, United States|Children’s and Women’s Health Centre of British Columbia (BC Children’s Hospital), Vancouver, British Columbia, V6H 3V4, Canada|London Health Sciences Center, London, Ontario, N6A 5A5, Canada|University Health Network-Toronto Western Hospital, Toronto, Ontario, M5T 2S8, Canada|LLC Arensia Exploratory Medicine, Tbilisi, 0112, Georgia|Epilepsiezentrum Berlin-Brandenburg, Berlin, 10365, Germany|Bethel Epilepsy Centre, Bielefeld, 33617, Germany|Univ.-Klinik Bonn, Klinik und Poliklinik fur Epileptologie, Bonn, 53127, Germany|Universitatsklinikym Frankfurt, Frankfurt, 60528, Germany|Universitatsklinikum Freiburg, Neurozentrum/Epilepsiezentrum, Freiburg, 79106, Germany|University Hospital Munster (UKM), Muenster, 48149, Germany|Klinikum Osnabruck, Osnabrück, 49076, Germany|Krankenhaus Barmherzige Brueder Regensburg, Regensburg, 93049, Germany|University of Tubingen-Dept. of Neurology and Epileptology, Tübingen, 72076, Germany|IRCCS- Istituto delle Scienze Neurologiche, Bellaria Hospital, Bologna, 40139, Italy|Dipartimento Scienze Mediche e Chirurgiche, Universita Magna Graecia di Catanzaro, Catanzaro, 88100, Italy|Fondazione IRCCS Istituto Neurologico C. Besta, Milano, 20133, Italy|IRCCS Istituto Neurologico Nazionale C. Mondino, Pavia, 27100, Italy|Azienda Ospedaliera Universita’ Pisana, Pisa, 56124, Italy|Azienda Ospedaliera “Bianchi-Melacrino-Morelle”di Reggio Calabria, Reggio Calabria, 89123, Italy|Policlinico di Roma Umberto I, Roma, 00185, Italy|PMSI Republican Clinical Hospital, ARENSIA Exploratory Medicine, Chisinau, 2025, Moldova, Republic of|Hospital Virgen Macarena, Sevilla, Andalusia, 41009, Spain|Centro de Neurologia Avanzada, Sevilla, Andalusia, 41013, Spain|Hospital Germans Trias I Pujol, Badalona, Barcelona, 08916, Spain|Clínica Universidad Navarra, Pamplona, Navarra, 31008, Spain|Hospital del Mar, Barcelona, 08003, Spain|Hospital Universitario Vall d’Hebron, Barcelona, 08035, Spain|Hospital Vithas La Salud, Granada, 18008, Spain|Hospital U. Ramón y Cajal, Madrid, 28034, Spain|Hospital Ruber Internacional, Madrid, 28036, Spain|Hospital U. Clínico San Carlos, Madrid, 28040, Spain|Hospital Universitario Fundacion Jimenez Diaz, Madrid, 28040, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|Hospital Regional Universitario de Málaga, Málaga, 29010, Spain|Hospital Universitario y Politécnico La Fe, Valencia, 46026, Spain|Hospital Clínico Universitario Valladolid, Valladolid, 47003, Spain|Medical Center of Limited Liability Company “Harmoniya Krasy”, Kyiv, 01135, Ukraine|Institute of Neurological Sciences, Glasgow, Scotland, G514TF, United Kingdom|University Hospital of Wales, Cardiff, Wales, CF14 4XW, United Kingdom|King’s College Hospital NHS Foundation Trust, London, SE5 9RS, United Kingdom|St. George’s University Hospitals NHS Foundation Trust, London, SW17 0QT, United Kingdom Less << |
Protocol
| Bio Calculators | ||||
| Preparing Stock Solutions |  |
1mg | 5mg | 10mg |
|
1 mM 5 mM 10 mM |
2.71mL 0.54mL 0.27mL |
13.57mL 2.71mL 1.36mL |
27.14mL 5.43mL 2.71mL |
|
Reviews
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