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  • Izorlisib
    • Izorlisib

    Izorlisib

    CAS No.: 1007207-67-1

    Category

    Cat.NO.:A197431  Purity:99%

    Product Details of Izorlisib

    CAS No. : 1007207-67-1
    Formula :

    C15H19N7O3S
    M.W :

    377.42

    SMILES Code :
    NC1=NC=C(C2=C3C(N(S(=O)(C)=O)CC3)=NC(N4CCOCC4)=N2)C=N1
    Synonyms :
    CH5132799; MEN1611; PA799
    MDL No. : MFCD22419020
    InChI Key : JEGHXKRHKHPBJD-UHFFFAOYSA-N
    Pubchem ID : 49784945

    Safety of Izorlisib

    GHS Pictogram:
    Signal Word: Warning
    Hazard Statements: H302-H315-H319-H335
    Precautionary Statements: P261-P305+P351+P338

    Related Pathways of Izorlisib

    PI3K-AKT

    Isoform Comparison

    Biological Activity

    Target

    • p110γ

      PI3Kγ, IC50:36 nM

    • p110β

      PI3Kβ, IC50:0.12 μM

    • p110α

      PI3Kα, IC50:14 nM

    • p110δ

      PI3Kδ, IC50:0.50 μM

    In Vitro:

    Cell Line

    		 Concentration Treated Time Description References
    Small-diameter trigeminal ganglion neurons 1 μM CH5132799, a selective inhibitor of class I PI3Ks, prevented the MC4R-mediated IA response PMC6462507

    Clinical Trial:

    NCT Number Conditions Phases Recruitment Completion Date Locations
    NCT01222546 Solid Tumors PHASE1 COMPLETED 2025-12-12 Investigator Sites, London, Le… More >>eds, United Kingdom Less <<

    Protocol

    Bio Calculators
    Preparing Stock Solutions 1mg 5mg 10mg

    1 mM

    5 mM

    10 mM

    2.65mL

    0.53mL

    0.26mL

    13.25mL

    2.65mL

    1.32mL

    26.50mL

    5.30mL

    2.65mL

    References

    [1]Tanaka H, Yoshida M, et al. The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin Cancer Res. 2011 May 15;17(10):3272-81.

    [2]Ohwada J, Ebiike H, et al. Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1767-72. doi: 10.1016/j.bmcl.2011.01.065. Epub 2011 Jan 22.

    [3]Tanaka H, Yoshida M, Tanimura H, Fujii T, Sakata K, Tachibana Y, Ohwada J, Ebiike H, Kuramoto S, Morita K, Yoshimura Y, Yamazaki T, Ishii N, Kondoh O, Aoki Y. The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin Cancer Res. 2011 May 15;17(10):3272-81.

     

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