Cat.NO.:A116912 Purity:97%
Product Details of [ 1007-16-5 ]
| CAS No. : | 1007-16-5 |
| Formula : |
C7H4BrFO2 |
| M.W : |
219.01
|
| SMILES Code : | O=C(O)C1=CC=C(F)C(Br)=C1 |
| MDL No. : | MFCD00042463 |
Safety of [ 1007-16-5 ]
| GHS Pictogram: |  |
| Signal Word: | Warning |
| Hazard Statements: | H315-H319-H335 |
| Precautionary Statements: | P261-P305+P351+P338 |
Application In Synthesis of [ 1007-16-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1007-16-5 ]
[ 1007-16-5 ] Synthesis Path-Downstream 1~3
- 1
[ 1007-16-5 ]
[ 74-88-4 ]
[ 206551-41-9 ]
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 89.5% | With potassium carbonate; In tert-butyl methyl ether; N,N-dimethyl-formamide; at 20℃; for 16h; | To a 100 mL round bottom flask was added 3-bromo-2-fluorobenzoic acid (5.00 g, 22.8 mmol, Oakwood), potassium carbonate (3.17 g, 22.9 mmol), and DMF (30 mL).Iodomethane, 2 M in MTBE (11.6 ml, 23.2 mmol) was added and the reaction mixture was stirred at RT for 16 hours. The reaction was filtered and the filtrate concentrated was in vacuo. The resulting brown crude residue was taken up with EtOAc and again filtered and concentrated to give methyl 3-bromo-2-fluorobenzoate (4.76 g, 20.4 mmol, 89.5percent yield), as a brown syrup that was used in the Step 2 without further purification. |
- 2
- [ 1007-16-5 ]
- [ 75-65-0 ]
[ 375368-94-8 ]
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| Exam ple 1E: Com pound 1OT7Step 1- Add carbonyi diimtcfazoie (3.68 g, 227 mmol) to a mixture of 3-bromo-4-fluoro benzoic acid 1e1 (2.51 g, 115 mmoi) in DMF (25 mL} and stir at RT for about 1 ft. Cool the reaction to CfC and add t-BuOH (5,7 ml, 59,4 mmol). Then add DBU (1.9 mL, 12,8 mmol) dropwise. Allow the mixture to warm to RT and stir for about 21 ft, Dilute the mixture with t-BME and wash successively with 10% titrie acid (aqueous) and saturated NaHCO^ (aqueous). Dry over MgSO4, filter and evaporate the votatiies to obtain 1e2. |
- 3
- [ 1007-16-5 ]
[ 369-26-6 ]
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