Sodium dihydrogen phosphate monohydrate,Sodium dihydrogen phosphate monohydrate

Cat.NO.:A809930,A1453167,A809930,A1453167 Purity:99%,99% +,AR,99%,99% +,AR

Product Details of Sodium dihydrogen phosphate monohydrate

CAS No. :	10049-21-5
Formula :	H₄NaO₅P
M.W :	137.99
SMILES Code :	O=P(O)([O-])O.[H]O[H].[Na+]
MDL No. :	MFCD00149208

Safety of Sodium dihydrogen phosphate monohydrate

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of Sodium dihydrogen phosphate monohydrate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 10049-21-5 ]
Downstream synthetic route of [ 10049-21-5 ]

[ 10049-21-5 ] Synthesis Path-Upstream 1~1

1
[ 10049-21-5 ]
[ 513-35-9 ]
[ 179174-79-9 ]

References:

[1] Patent: US5849943, 1998, A, .

[ 10049-21-5 ] Synthesis Path-Downstream 1~2

1
[ 7758-19-2 ]
[ 10049-21-5 ]
[ 146137-79-3 ]
[ 146328-87-2 ]

Yield	Reaction Conditions	Operation in experiment
	With dihydrogen peroxide; sodium sulfite; In water; acetonitrile;	PREPARATION 88(2) To a solution of <strong>[146137-79-3]5-cyano-2-fluorobenzaldehyde</strong> (145 mg) in acetonitrile (2 mL) were added a sodium dihydrogenphosphate aqueous solution (23 mg in 1 mL water) and 30percent hydrogen peroxide (0.09 mL). To the resulting mixture was added dropwise a sodium chlorite aqueous solution (126mg in 1 mL water) for an hour at 0° C. The mixture was stirred for an hour at ambient temperature, then a small amount of sodium sulfite was added. The mixture was diluted with ethyl acetate and washed successively with 1N-hydrochloric acid and brine. The organic layer was dried over sodium sulfate and evaporated in vacuo. The residue was triturated with diisopropyl ether to give 5-cyano-2-fluorobenzoic acid (137 mg) as a solid substance. NMR (DMSO-d6, delta): 7.29 (1H, t, J=9 Hz), 7.83 (1H, m), 8.32 (1H, dd, J=2, 7 Hz); Mass m/z: 164 (M+-1).

References: [1]Patent: US6384080,2002,B1 .

2
[ 10049-21-5 ]
[ 7790-86-5 ]
[ 203661-55-6 ]
[ 15469-97-3 ]
[ 203655-46-3 ]

Yield	Reaction Conditions	Operation in experiment
	With n-butyllithium; sodium chloride; In tetrahydrofuran; hexane; ethyl acetate;	(10-Methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)-[1-(triphenylmethyl)imidazol-2-yl]methanol 50 ml of a solution of 1.32 g of 1-(triphenylmethyl)imidazole in dry tetrahydrofuran was ice-cooled in a nitrogen atmosphere. After adding 2.8 ml of a 1.6 M solution of n-butyllithium in hexane, the resulting mixture was stirred for 2 hours. Then the reaction mixture was cooled to -78° C. After adding 1.23 g of cerium (III) chloride, the reaction mixture was stirred for 30 minutes. Further, 40 ml of a solution of 0.546 g of (10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)carbaldehyde in dry tetrahydrofuran was dropped thereinto. Then the reaction mixture was brought back to room temperature and distributed into an aqueous solution of sodium dihydrogenphosphate and ethyl acetate. After filtering off the inorganic matters, the aqueous layer was extracted with ethyl acetate, washed successively with water and a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate followed by filtration. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol) to thereby give 716 mg of the title compound as a yellow solid. 1H-NMR(CDCl3) delta ppm: 2.84(d, J=8 Hz, 1H), 3.44(s, 3H), 4.98(d, J=8 Hz, 1H), 5.07(d, J=9 Hz, 1H), 5.19(d, J=9 Hz, 1H), 6.40(dd, J=2, 8 Hz, 1H), 6.68(d, J=8 Hz, 1H), 6.77(d, J=2 Hz, 1H), 6.78(d, J=2 Hz, 1H), 7.09-7.12(m, 7H), 7.23-7.26(m, 9H), 7.82(s, 2H)

References: [1]Patent: US6518423,2003,B1 .

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Sodium dihydrogen phosphate monohydrate,Sodium dihydrogen phosphate monohydrate

Product Details of Sodium dihydrogen phosphate monohydrate

Safety of Sodium dihydrogen phosphate monohydrate

Application In Synthesis of Sodium dihydrogen phosphate monohydrate

[ 10049-21-5 ] Synthesis Path-Upstream 1~1

[ 10049-21-5 ] Synthesis Path-Downstream 1~2

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