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Application In Synthesis of p-Dimethylaminobenzaldehyde

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

• Downstream synthetic route of [ 100-10-7 ]

[ 100-10-7 ] Synthesis Path-Downstream   1~35

• 1
• [ 86-71-5 ]
• 
• [ 100-10-7 ]
• 
• <i>N</i>³,<i>N</i>⁶-bis-(4-dimethylamino-benzylidene)-carbazole-3,6-diyldiamine [ No CAS ]

References: [1]Journal of Polymer Science, Part A: Polymer Chemistry,2018,vol. 56,p. 2692 – 2700.
[2]Chemisches Zentralblatt,1913,vol. 84,p. 2130.

• 2
• [ 66379-84-8 ]
• 
• [ 115282-41-2 ]
• 
• [ 100-10-7 ]

References: [1]Bulletin de la Societe Chimique de France,1920,vol. &lt;4&gt; 27,p. 50.

• 3
• [ 38480-94-3 ]
• 
• [ 100-10-7 ]
• 
• 4-dimethylamino-2′,3′-dimethoxy-chalcone [ No CAS ]

References: [1]Helvetica Chimica Acta,1924,vol. 7,p. 335.

• 4
• [ 3167-63-3 ]
• 
• [ 100-10-7 ]
• 
• [ 58898-16-1 ]

References: [1]Synthesis,1976,p. 197 – 199.

• 5
• [ 326-62-5 ]
• 
• [ 100-10-7 ]
• 
• [ 390-98-7 ]

References: [1]Bulletin des Societes Chimiques Belges,1960,vol. 69,p. 312 – 322.

• 6
• [ 1836-05-1 ]
• 
• [ 100-10-7 ]
• 
• [ 1774-68-1 ]

References: [1]Monatshefte fur Chemie,1965,vol. 96,p. 450 – 460.

• 7
• [ 100-10-7 ]
• 
• [ 13214-64-7 ]
• 
• [ 110145-16-9 ]

References: [1]Journal of Chemical Sciences,2011,vol. 123,p. 335 – 341.
[2]Journal of the Chemical Society,1960,p. 3457 – 3461.

• 8
• [ 54109-03-4 ]
• 
• [ 100-10-7 ]
• 
• [ 95834-48-3 ]

References: [1]Bulletin of the Academy of Sciences of the USSR Division of Chemical Science,1985,vol. 34,p. 141 – 144.

    Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,1985,p. 151 – 155.

• 9
• [ 82104-74-3 ]
• 
• [ 100-10-7 ]
• 
• 5-cyano-2-(p-dimethylaminophenyl)indan-1,3-dione [ No CAS ]

References: [1]Bulletin of the Academy of Sciences of the USSR Division of Chemical Science,1986,vol. 35,p. 1680 – 1684.

    Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,1986,p. 1850 – 1855.

• 10
• [ 2478-38-8 ]
• 
• [ 100-10-7 ]
• 
• [ 127034-26-8 ]

References: [1]Journal of Medicinal Chemistry,1990,vol. 33,p. 1948 – 1954.

• 11
• [ 5978-75-6 ]
• 
• [ 100-10-7 ]
• 
• [ 123500-13-0 ]

References: [1]Tetrahedron,1989,vol. 45,p. 1723 – 1746.

• 12
• [ 14205-39-1 ]
• 
• [ 100-10-7 ]
• 
• [ 50607-30-2 ]
• 
• 3-carbomethoxy-2-methyl-5-oxo-4-(4-N-dimethylaminophenyl)-1,4,5,6,7,8-hexahydro-pyrido<4,3-b>pyridine [ No CAS ]

References: [1]Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry,1995,vol. 34,p. 17 – 20.

• 13
• [ 66379-84-8 ]
• 
• alkalies [ No CAS ]
• 
• [ 115282-41-2 ]
• 
• [ 100-10-7 ]

References: [1]Bulletin de la Societe Chimique de France,1920,vol. &lt;4&gt; 27,p. 50.

• 14
• [ 24629-25-2 ]
• 
• [ 100-10-7 ]
• 
• [ 462102-43-8 ]

References:

• 15
• [ 67-56-1 ]
• 
• [ 100-10-7 ]
• 
• [ 1202-25-1 ]

References: [1]Chemical Science,2016,vol. 7,p. 4428 – 4434.
[2]Mendeleev Communications,2005,vol. 15,p. 207 – 208.
[3]Journal of Medicinal Chemistry,2016,vol. 59,p. 655 – 670.

• 16
• [ 57497-39-9 ]
• 
• [ 100-10-7 ]
• 
• [ 98236-04-5 ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 3572 – 3578.

• 17
• [ 3199-50-6 ]
• 
• [ 100-10-7 ]
• 
• 1-(5-bromo-2-furanyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 6388 – 6396.

• 18
• [ 100-10-7 ]
• 
• [ 115282-41-2 ]

References: [1]Chemische Berichte,1902,vol. 35,p. 3572.

• 19
• [ 120-35-4 ]
• 
• [ 100-10-7 ]
• 
• 3-(4-Dimethylamino-benzylamino)-4-methoxy-N-phenyl-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Example 268 3-(4-Dimethylamino-benzylamino)-4-methoxy-N-phenyl-benzamide The title compound has been made using the procedure of Example 50, but using 3-amino-4-methoxy-N-phenyl benzamide and 4-dimethylaminobenzaldehyde as starting materials, which can be purchased from Aldrich; m.p. 195-197 C.

References: [1]Patent: US6268387,2001,B1 .

• 20
• [ 3199-50-6 ]
• 
• aqueous potassium hydroxide [ No CAS ]
• 
• [ 100-10-7 ]
• 
• 1-(5-bromo-2-furanyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
55.4%	In ethanol;	Synthesis of 1-(5-bromo-2-furanyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one (32) Compound 29 (500 mg, 2.65 mmol) and 4-dimethylaminobenzaldehyde (394 mg, 2.65 mmol) were dissolved in ethanol (5 mL), followed by addition of 10% aqueous potassium hydroxide (10 mL). The mixture was stirred at room temperature for 1 h, and then the precipitated crystals were collected by filtration and washed with 50% aqueous ethanol to obtain Compound 32. Yield 470 mg (yield rate 55.4%). 1H NMR (300 MHz, CDCl3) delta 3.04 (s, 6H), 5.22 (d, J=3.9 Hz, 1H), 6.80 (d, J=3.6 Hz, 1H), 6.89 (d, J=15.0 Hz, 1H), 7.46 (d, J=14.7 Hz, 1H), 7.70 (d, J=8.1 Hz, 2H), 7.81 (d, J=8.7 Hz, 2H). MS m/z 321 (MH+).

References: [1]Patent: US2010/278733,2010,A1 .

• 21
• [ 3199-50-6 ]
• 
• [ 100-10-7 ]
• 
• 1-(5-bromo-2-furanyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
55.4%	With potassium hydroxide; In ethanol; water; at 20℃; for 1h;	Synthesis of 1-(5-bromo-2-furanyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one (32) Compound 29 (500 mg, 2.65 mmol) and 4-dimethylaminobenzaldehyde (394 mg, 2.65 mmol) were dissolved in ethanol (5 mL), followed by addition of 10% aqueous potassium hydroxide (10 mL). The mixture was stirred at room temperature for 1 h, and then the precipitated crystals were collected by filtration and washed with 50% aqueous ethanol to obtain Compound 32. Yield 470 mg (yield rate 55.4%). 1H NMR (300 MHz, CDCl3) delta 3.04 (s, 6H), 5.22 (d, J = 3.9 Hz, 1H), 6.80 (d, J = 3.6 Hz, 1H), 6.89 (d, J = 15.0 Hz, 1H), 7.46 (d, J = 14.7 Hz, 1H), 7.70 (d, J = 8.1 Hz, 2H), 7.81 (d, J = 8.7 Hz, 2H). MS m/z 321 (MH+).

References: [1]Patent: EP2030635,2009,A1 .Location in patent: Page/Page column 26; 50.

• 22
• [ 92138-20-0 ]
• 
• [ 100-10-7 ]
• 
• [ 956291-32-0 ]

References: [1]Bioorganic and Medicinal Chemistry,2009,vol. 17,p. 6937 – 6941.

• 23
• [ 54589-54-7 ]
• 
• [ 100-10-7 ]
• 
• [ 1241941-28-5 ]

References: [1]Angewandte Chemie – International Edition,2010,vol. 49,p. 4665 – 4668.

• 24
• [ 326-62-5 ]
• 
• [ 100-10-7 ]
• 
• [ 1361504-11-1 ]

References: [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 2858 – 2868.

• 25
• [ 100-10-7 ]
• 
• [ 1668-54-8 ]
• 
• [ 1465739-99-4 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 5968 – 5970.

• 26
• [ 5654-97-7 ]
• 
• [ 100-10-7 ]
• 
• (Z)-3-(4-(dimethylamino)benzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one [ No CAS ]
• 
• (E)-3-(4-(dimethylamino)benzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2015,vol. 58,p. 6002 – 6017.

• 27
• [ 1836-05-1 ]
• 
• [ 100-10-7 ]
• 
• (E)-1-(3-bromo-2-hydroxyphenyl)-3-(4-(dimethylamino)phenyl)prop-2-en-1-one [ No CAS ]

References: [1]Organic and Biomolecular Chemistry,2015,vol. 13,p. 9418 – 9426.

• 28
• [ 85279-30-7 ]
• 
• [ 100-10-7 ]
• 
• (E)-3-(4-(dimethylamino)phenyl)-1-(3-methylpyridin-2-yl)prop-2-en-1-one [ No CAS ]

References: [1]Organic and Biomolecular Chemistry,2015,vol. 13,p. 9418 – 9426.

• 29
• [ 78364-55-3 ]
• 
• [ 100-10-7 ]
• 
• 2-[2-(4-(N,N-dimethylamino)benzylidene)hydrazino]-6-fluorobenzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.
	In ethanol; at 70 – 80℃; for 3h;	General procedure: The mixture of <strong>[78364-55-3]6-fluoro-2-hydrazinylbenzo[d]thiazole</strong> (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 °C for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. T Details Products CAS 50-54-4 Read more Products CAS 57-22-7 Read more Products CAS 53-64-5 Read more Reviews There are no reviews yet. Be the first to review “p-Dimethylaminobenzaldehyde” Cancel reply Your email address will not be published. Required fields are marked * Your rating * Rate… Perfect Good Average Not that bad Very poor Your review * Name * Email * Save my name, email, and website in this browser for the next time I comment. Previous 3-Bromo-4,5-dichloropyridine Next 1-{1-[(4-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl}ethan-1-one